Identification of Lethal Alleles
Predicting the presence of a lethal allele can be easier with the help of the following methods:
- Genetic Crosses: Genetic crosses between individuals with known genotypes can help in the identification of lethal alleles. By observing the outcomes of the crosses, the presence of a lethal allele can be understood based on the inheritance pattern.
- Analysis of Offspring Ratios: Lethal alleles result in an altered phenotypic ratio. It can be better understood with the help of the following example, if a lethal allele is present, a reduced frequency in the presence of that allele (in homozygous individuals) can be seen. Deviations from the expected ratios can indicate lethal allele presence.
- Molecular Genetics: Modern techniques in molecular genetics such as DNA sequencing and PCR (polymerase chain reaction) can help in analysing the individual’s DNA and the associated mutations. The genetic basis of the fatality or lethality can be revealed by comparing the DNA sequences of individuals with the presence or absence of a lethal phenotype.
Lethal Allele – Examples, & its Types
Lethal Alleles are gene mutations that hamper the survival of an organism. They can present as various genetic disorders which are fatal to the individual. They are identified with the help of techniques such as gene mapping, molecular genetics, genetic crosses, and so on. Identifying them is essential to be prepared with a perfect treatment strategy to fight the upcoming disorder.
Table of Content
- Lethal Allele Definition
- What are Lethal Alleles?
- Lethal Allele Examples
- Types of Lethal Allele
- Causes of Lethal Alleles
- Identification of Lethal Alleles
- Effect of Lethal Alleles on Various Populations
- Diseases due to Lethal Alleles