Krebs Cycle Enzymes
In eukaryotic cells, the enzymes orchestrating the citric acid cycle reactions reside within the mitochondria’s matrix, with exceptions like succinate dehydrogenase and aconitase, found in the inner mitochondrial membrane. A shared feature among these enzymes is their dependence on Mg2+ for catalytic activity.
The citric acid cycle involves several enzymatic steps, each facilitated by a specific enzyme:
- Citrate synthase
- Aconitase
- Isocitrate dehydrogenase
- α-ketoglutarate dehydrogenase
- Succinyl-CoA synthetase
- Succinate dehydrogenase
- Fumarase
- Malate dehydrogenase
Krebs Cycle or Citric Cycle
Kreb Cycle (Citric Acid Cycle, or TCA cycle (tricarboxylic acid cycle)), is a central metabolic pathway where the sequence of biochemical reactions releases energy stored in the form of ATP. The Krebs Cycle takes place in the mitochondria. The Krebs Cycle was discovered by Hans Krebs.
The cycle starts with acetyl-CoA which is derived from carbohydrates, fats, and proteins. It enters the cycle and gets converted into citrate, a six-carbon molecule. In this article, we will cover the Krebs cycle, its location, steps, and significance.
Table of Content
- What is Kreb Cycle?
- Where Does Kreb Cycle Takes Place?
- Krebs Cycle Diagram
- Kreb Cycle is a Part of Cellular Respiration
- Kreb Cycle Steps
- Krebs Cycle Enzymes
- Regulation of Krebs Cycle
- Kreb Cycle Products
- Krebs Cycle Equation/Reaction
- Krebs Cycle Summary
- Krebs Cycle Function
- Importance of Kreb Cycle