Krebs Cycle Summary
Location – Takes place in the mitochondria of eukaryotic cells and the protoplasm of prokaryotic cells.
Steps of the Krebs Cycle – The various steps involved are:
- Acetyl-CoA Formation
- Acetyl-CoA combines with oxaloacetate to form citrate.
- Isomerization
- Citrate is converted to isocitrate.
- Decarboxylation
- Isocitrate undergoes oxidative decarboxylation to form α-ketoglutarate, releasing CO2 and producing NADH.
- Second Decarboxylation
- α-ketoglutarate is decarboxylated to form succinyl-CoA, releasing CO2 and producing NADH.
- Succinyl-CoA Formation
- Succinyl-CoA is produced from α-ketoglutarate, generating GTP/ATP and NADH.
- Succinate Formation
- Succinyl-CoA is converted to succinate, producing FADH2.
- Fumarate Formation
- Succinate is oxidized to form fumarate, generating FADH2.
- Malate Formation
- Fumarate is hydrated to form malate.
- Regeneration of Oxaloacetate
- Malate is oxidized to regenerate oxaloacetate, producing NADH.
End Product – 4CO2, 6 NADH, 2 FADH2, and 2 ATPs.
Krebs Cycle or Citric Cycle
Kreb Cycle (Citric Acid Cycle, or TCA cycle (tricarboxylic acid cycle)), is a central metabolic pathway where the sequence of biochemical reactions releases energy stored in the form of ATP. The Krebs Cycle takes place in the mitochondria. The Krebs Cycle was discovered by Hans Krebs.
The cycle starts with acetyl-CoA which is derived from carbohydrates, fats, and proteins. It enters the cycle and gets converted into citrate, a six-carbon molecule. In this article, we will cover the Krebs cycle, its location, steps, and significance.
Table of Content
- What is Kreb Cycle?
- Where Does Kreb Cycle Takes Place?
- Krebs Cycle Diagram
- Kreb Cycle is a Part of Cellular Respiration
- Kreb Cycle Steps
- Krebs Cycle Enzymes
- Regulation of Krebs Cycle
- Kreb Cycle Products
- Krebs Cycle Equation/Reaction
- Krebs Cycle Summary
- Krebs Cycle Function
- Importance of Kreb Cycle