Major Histocompatibility Complex (MHC) Class I
- MHC Class I is present in every nucleated cell except the nervous tissues & the platelets.
- The size of the MHC Class I is 45 KD. These are the group of the major histocompatibility antigens
- It was only able to work with Tc cells. These T lymphocytes help to destroy foreign elements.
- It only works with the cell-mediated immune response. It only comes out to the surface whenever there is such a response.
- It can able to bind with the CD-8 adhesion molecule of the T lymphocytes.
- There are three types of HLA genes present inside a Major Histocompatibility Complex (MHC) Class I.
- MHC Class I attaches to endogenous antigens.
Structure Of Major Histocompatibility Complex (MHC) Class I
The structure of the MHC Class I is completely simple. It is a chain-like structure. The whole structure is made up of a chain. It is similar to the RNA structure. The chain has one end inside the membrane of the cell. The other end makes the structure of the MHC Class I. There are mainly three folds on the structure. They all are made up of a bend of the chain.
There are two chains present. One is Alpha Chain & another is the Beta chain. Their chain is made up of the polypeptide molecule. There are three domains of alpha. They are Alpha1, Alpha2, Alpha3. There is only one domain of the Beta. The beta is completely detached from the cell membrane. The chain that is connected with the cell membrane, is made up of the domains of the Alpha.
Alpha chains are non-covalently attached to the Beta. Also, there are transmembrane glycoproteins on the alpha domains. They act as the HLA gene. There are two di-sulfate bonds in the Alpha2 & Beta domain. They help to make a tight bond there.
Major Histocompatibility Complex(MHC)
The immune system is the most essential system of our body. It not only helps to protect the creature from foreign substances. Also, it helps to grow up without any outside disturbance. The immune system protects us from various threats. It protects from various foreign substances. It identifies them & destroys them. so, that the animal can able to grow up without any issues. Sometimes it is assumed that Immune System is only made with the White Blood Corpuscles. But that is not a correct assumption. It is a complete system where different components & proteins play an important role. Major Histocompatibility complexes (MHC) are similar kinds of a substance.