Preparation of Glutaric Acid
- Glutaric acid can be synthesized from malonic ester synthesis, where diiodomethane reacts with the two-molar equivalent of diethyl malonate.
- It can be prepared by the oxidative ring fission of cyclopentane with 50% of nitric acid in the presence of vanadium cyanide.
- It is produced as a by-product in the production of adipic acid from cyclohexane by oxidation with air and nitric acid.
- We can also prepare glutaric acid by reacting 1,3-dibromopropane with sodium or potassium cyanide to produce the dinitrile, followed by hydrolysis.
Glutaric Acid Formula
Glutaric acid, also termed pentanedioic acid or n-pyrotartaric acid, is an alpha, omega-dicarboxylic acid with the formula C3H6(COOH)2. The body naturally produces glutaric acid as a by-product during the metabolism of some amino acids, such as lysine and tryptophan. It is an organic compound that appears as colorless crystals or white solids. It decomposes slightly at a temperature of 302-304 °C. At room temperature, the solubility of the related “linear” dicarboxylic acids adipic and succinic acids in water is only a few percent, whereas glutaric acid has a water-solubility of approximately 50% (w/w). Its conjugate bases are glutarate (1-) and glutarate. It functions as both a human and a Daphnia Magna metabolite. Glutaric acid is used as a precursor in organic synthesis.