Regulation of Urea Cycle
Regulation of the urea cycle involves with N-acetyl glutamate (NAG) and Substrate Concentrations. Let us discuss.
N-acetyl glutamate (NAG)
- NAG activates CPS I enzyme.
- NAG produced by the acetyl CoA and glutamate by using NAG synthase.
- Arginine and glutamic acid help speed up this process. Glutamic acid plays a double role as both a starting material and a booster for the urea cycle.
Substrate Concentrations
- Most enzymes work depends on how much of their substrates they have. Arginase is excluded from this process.
Urea Cycle – Steps, Disorders and Significance
The steps of the urea cycle generally consist of the five reactions in the mitochondrial matrix and the cytosol. The urea cycle also known as the ornithine cycle or the Krebs-Henseleit cycle is a series of different biochemical reactions that produce urea from ammonia in the ureotelic organisms.
The whole process takes place in the mitochondria of the liver cells. This cycle is a major metabolic pathway to remove nitrogen from the body with ammonia and carbon dioxide. A urea cycle needs 4 ATP to complete the whole process which is irreversible. In this article, we are going to discuss the different steps of the Urea Cycle in detail.
Table of Content
- What is Urea Cycle?
- What are the 5 Steps of Urea Cycle?
- Urea Cycle Diagram
- Regulation of Urea Cycle
- Energetics and Overall Reaction of Urea Cycle
- What is the Significance of Urea Cycle?
- Urea Cycle Disorders