Retrovirus Examples

Retroviruses are a family of viruses that are classified by their structure and how they replicate in a host. Some examples of retroviruses are:

Human immunodeficiency virus (HIV)

Human immunodeficiency virus (HIV) is a virus that weakens the body’s immune system by destroying cells that fight disease and infection. HIV spread through contact with certain bodily fluids of an infected person, including blood, breast milk, semen, and vaginal fluids. It does not spread by kisses, hugs, or sharing food. HIV can also spread from a mother to her baby. If left untreated, HIV can lead to AIDS, the late stage of HIV infection when the body’s immune system is badly damaged. There is currently no cure for HIV, but it can be controlled with proper medical care.

Human T-lymphotropic virus type 1 (HTLV-1)

Human T-lymphotropic virus type 1 (HTLV-1) is a virus that infects T cells, a type of white blood cell, and can cause leukemia and lymphoma. It’s also known as human T-cell leukemia virus type 1, or adult T-cell lymphoma virus type 1. HTLV-1 is spread by sharing needles or syringes, through blood transfusions, or from mother to child during birth or breastfeeding. 

Human T-lymphotropic virus type 2 (HTLV-2)

Human T-lymphotropic virus type 2 (HTLV-2) is a retrovirus that can infect cells of the monocyte/macrophage lineage. It’s associated with rare hematologic malignancies, such as atypical hairy cell leukemia, large granular lymphocytic leukemia, and mycosis fungoides.

Retrovirus

Retrovirus replication initiates with the attachment of viral envelope proteins to specific receptors on host cell membranes. Subsequently, the virus fuses with the host cell membrane, releasing viral RNA into the cytoplasm. The enzyme reverse transcriptase converts the viral RNA into DNA, which then integrates into the host cell’s genome.

Host cellular machinery transcribes the integrated viral DNA into RNA, translating it into viral proteins. In this article, we will study the structure, life cycle, and replication of retrovirus with examples.

Table of Content

  • What is Retrovirus?
  • Structure of Retrovirus
  • Retrovirus Genome
  • Retrovirus Life Cycle
  • Retrovirus Replication Steps
  • Difference Between Retrovirus And Virus
  • Retroviral Vectors
  • Retrovirus Examples
  • Endogenous Retrovirus

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What is Retrovirus?

Definition of Retrovirus: A retrovirus is a type of RNA virus that replicates by converting its RNA genome into DNA which is then integrated into the host cell’s genome....

Structure of Retrovirus

Retroviruses are spherical particles, usually 100–200 nanometers in diameter, that have an envelope and a core. The structure of the retrovirus is explained in detail below:...

Retrovirus Genome

Retroviruses are a type of virus that use RNA as their genetic material. They are named for the enzyme reverse transcriptase, which is a vital part of their life cycle. This RNA genome typically ranges from around 7,000 to 12,000 nucleotides in length. Retroviruses are “retro” because they reverse the normal gene-copying process....

Retrovirus Life Cycle

The life cycle of a retrovirus can be divided into two phases: the early phase and the late phase. The early phase includes the steps of infection from cell binding to the integration of the viral cDNA into the cell genome. The late phase begins with the expression of viral genes....

Retrovirus Replication Steps

Retroviruses, like HIV, have a unique replication process that combines lytic and lysogenic elements. The steps of retrovirus replication are:...

Difference Between Retrovirus And Virus

The difference between retrovirus and virus are:...

Retroviral Vectors

Retroviral vectors are modified retroviruses used as tools in genetic engineering and gene therapy. These vectors are designed to deliver specific genes into target cells by taking advantage of the retroviral life cycle. Retroviral vector is characterised by their ability to integrate the transgene into the host cell’s genome, resulting in stable and long-term gene expression. Retroviral vector design involves:...

Retrovirus Examples

Retroviruses are a family of viruses that are classified by their structure and how they replicate in a host. Some examples of retroviruses are:...

Endogenous Retrovirus

Endogenous retroviruses (ERVs) are remnants of retroviruses that are no longer infectious. They are a part of the genome and are similar to exogenous retroviruses, but are not infectious. ERVs are important components of the antiviral immune response. They regulate cellular immune activation and may even directly target invading viral pathogens. ERVs are also involved in pathological processes such as virus infection, immune response, and aging....

Conclusion: Replication of Retrovirus

Retroviruses are a large and diverse family of RNA viruses that use reverse transcriptase to transcribe RNA into DNA. They are distinguished from other viruses by the presence of reverse transcriptase. Retrovirus replication occurs when a retrovirus enters a host cell and the reverse transcriptase enzyme converts the retroviral RNA genome into double-stranded DNA. This DNA then migrates to the nucleus and becomes integrated into the host genome. The viral genes are transcribed and translated, and new virus particles assemble, exit the cell, and infect others....

FAQs on Replication of Retrovirus

What are Retroviruses?...