What is DHEA(Dehydroepiandrosterone)?

Dehydroepiandrosterone (DHEA) is a steroid hormone produced mainly by the adrenal glands, which are located on top of the kidneys. It is classified as an androgen. DHEA is produced in both males and females but the levels tend to be higher in males.

Key points about DHEA

• Hormone Production: DHEA is produced in the adrenal glands through a series of enzymatic reactions from cholesterol. It is secreted in a diurnal (daily) rhythm with levels typically highest in the morning and gradually declining throughout the day.
• Age-related Decline: DHEA levels peak in the early to mid-20s and gradually decline with age. By the time individuals reach their 70s, DHEA production is significantly reduced.
• Biological Effects: DHEA serves as a precursor for the production of sex hormones, such as estrogen and testosterone. It plays a role in maintaining the balance of these hormones in the body. DHEA also has additional physiological effects, including potential effects on mood, energy, muscle strength, and overall well-being.
• Clinical Applications: DHEA supplementation has been studied for various conditions, including hormone imbalances, aging-related symptoms, and certain disorders. However, the clinical applications of DHEA supplementation are still being researched, and its long-term effects and optimal dosages require further investigation.
• Measurement: DHEA levels can be measured in blood or saliva samples. Typically, free DHEA (unbound to proteins) is measured to assess its availability for conversion into other hormones.

Difference Between DHEA and DHEA-S: DHEA (Dehydroepiandrosterone) and DHEA-S (Dehydroepiandrosterone sulfate) are both hormones that are produced by the adrenal glands. They are precursors to hormones such as estrogen and testosterone and play various roles in the body. However, there are some key differences between DHEA and DHEA-S.