Wurtz Fittig Reaction Distinction
Wurtz Fittig Reaction closely resembles the Wurtz Reaction but has difference, particularly in its application to Aryl Halides. While the Wurtz Reaction is effective for alkyl halides, the Wurtz Fittig Reaction extends its application to Aryl Halides, allowing for the coupling of aromatic compounds in the presence of reactive metals. The mechanism remains similar, with the coupling of halides facilitated by the formation of radicals and subsequent nucleophilic attacks, but the broader scope makes the Wurtz Fittig Reaction a versatile tool in organic synthesis.
Comparison of Wurtz Reaction, Fittig Reaction, and Wurtz Fittig Reaction
A detailed comparison between Wurtz Reaction, Fittig Reaction and Wurtz Fittig Reaction is tabulated below:
| Aspect | Wurtz Reaction | Fittig Reaction | Wurtz Fittig Reaction |
|---|---|---|---|
| Type of Compounds | Alkyl halides | Aryl halides | Both Alkyl and Aryl halides |
| Reactive Metal | Sodium or Potassium | Sodium or Potassium | Sodium or Potassium |
| Formation | Carbon-carbon bond between alkyl halides | Carbon-carbon bond between aryl halides | Carbon-carbon bond between alkyl and aryl halides |
| Applicability | Synthesis of symmetrical alkanes | Synthesis of symmetrical biaryls | Broad synthesis, coupling alkyl and aryl halides |
| Mechanism | Radical mechanism involving alkyl radicals | Radical mechanism involving aryl radicals | Combination of alkyl and aryl radical mechanisms |
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Wurtz-Fittig Reaction
Wurtz Fittig Reaction is a chemical process related to the classic Wurtz Reaction. It is primarily used to join alkyl and aryl halides, commonly chlorides, bromides, or iodides in the presence of sodium metal and dry ether. This reaction is similar to the Wurtz Reaction, and results in the formation of a new carbon-carbon bond and merge two smaller alkyl or aryl molecules into a larger one.
In this article, we will learn in detail about the Wurtz Fittig Reaction, its equation, example, uses, and comparison with the Wurtz and the Fittig Reaction.
Table of Content
- What is Wurtz Fittig Reaction?
- Wurtz Fittig Reaction Equation
- Wurtz-Fittig Reaction Mechanism
- Uses of Wurtz Fittig Reaction
- Limitations of Wurtz Fittig Reaction
- Wurtz Fittig Reaction Distinction